Northern Foods rejected City suggestions that it would fail to get the £200m it was seeking for the pastry, cakes, speciality bread and flour milling businesses.Remaining disposals were “progressing in line with plans to achieve £200m total proceeds” said Northern, as it unveiled a 38% fall in pre-tax profit on continuing and discontinued operations to £16m from £25.7m a year before. Sales fell 2.4% to £645.1m.It blamed the profit drop on continued “challenging” trading conditions, the move of some seasonal sales into this half of the current financial year and the sale of the NFT distribution business.However, the NFT sale produced gross proceeds of £51.2m and, taking into account discontinued operations and £17.7m of exceptional items, produced a £30.5m profit in the first half – up from £14.4m a year before.Still up for sale are Northern’s chilled pastry, cakes, speciality bread and flour milling businesses, with the aim of focusing on the remaining pizza, biscuit, readymeal, sandwich and salad and Christmas pudding operations. The businesses to be sold off accounted for 37.4% of total revenue of £683.2m in the first half but only 5.2% of the £26.7m operating profit.The operating profit of Northern’s bakery division slumped by 65% to £6.6m from £18.6m a year before because of poor performances by both the businesses up for sale and those Northern plans to keep. The bakery division’s sales fell 10.2% year-on-year to £196.5m, on the back of a 7.6% fall in sales volumes and a 2.6% fall in average net selling prices.Northern has withdrawn its long-running objection to an attempt by the Melton Mowbray Pork Pie Association to win Protected Geographical Indication (PGI) status in the EU for Melton Mowbray pies.
NEW YORK, NY – Wimbledon champions Andy Murray and Serena Williams powered into the second round of the US Open as the stars came out on Arthur Ashe Stadium court on Tuesday night.Williams, launching her latest bid to rewrite the record books, started strong and didn’t let up in 6-3, 6-3 victory over 29th-ranked Ekaterina Makarova.The US world number one appeared untroubled by the baulky right shoulder that has hindered her in recent weeks, delivering a dozen aces and 27 winners overall in the 63-minute contest.“I knew today I needed to be focused because I’ve played her. She’s gotten to the semi-finals. She goes deep in majors,” Williams said of the Russian left-hander who beat her in the fourth round of the 2012 Australian Open.“She knows how to play big matches on big courts. She’s not intimidated. I knew I had to really come out today. It was my only option really.”Williams said she wouldn’t know until she’d slept on it how her shoulder might respond to the effort.“Every day, I’ll just see how it goes,” said Williams, who is chasing a record seventh title on the hard courts of Flushing Meadows where she first triumphed in 1999.A victory would see her break the Open Era record of 22 Grand Slam titles she now shares with German Steffi Graf and close in on Margaret Court’s all-time mark of 24 major titles.While Williams has struggled since Wimbledon, Murray went from claiming a second title at the All England club to a successful defence of his Olympic gold in Rio.Vying to become the fourth man in the Open Era to reach all four major finals in a calendar year, Murray, too, produced a dominant service performance in a 6-3, 6-2, 6-2 victory over Czech Lukas Rosol.“I don’t think I had any break points against me, which is very good,” the Scot said. (AFP)
Researchers at the Department of Molecular Microbiology and Immunology at the Keck School of Medicine of USC have discovered that the UV radiation Resistance Associated Gene could help prevent the onset of the skin cancer melanoma in high-risk individuals in a study that was conducted earlier this month. Lead researcher and associate professor Chengyu Liang and her team published their findings in Molecular Cell on May 19 during Melanoma/Skin Cancer Detection and Prevention Month.The study found that UVRAG is heavily involved in a cell’s repair process following exposure to UV radiation. Proteins scan for impaired DNA and tag the gene to repair lesions. The expression of this gene is also directly related to survival rates and the metastasis of the cancer.“The higher the UVRAG, the better the survival rate, and the slower the tumor progression,” Liang said in an email to the Daily Trojan. “The UV-protecting function of UVRAG allows the cells to repair UV-induced DNA damage efficiently, reducing the UV-induced genetic instability, thereby protecting against skin cancer.”The UVRAG gene was discovered almost 20 years ago, but until the study conducted by USC researchers, the biological pathway, expression and function of the gene was unknown.The study found that individuals with mutated versions of the gene will be more susceptible to melanoma, which is the deadliest type of skin cancer, claiming the lives of 10,130 people annually, according to the American Cancer Society.“Without UVRAG or when UVRAG is reduced, the core machinery involved in damage repair cannot assemble efficiently, instead rather idle apart, leaving many damage unfixed,” Liang said. “Accumulation of such unfixed DNA errors increases the genetic instability, highly increasing the risk of melanoma and other skin cancer.”The study compared the repaired damage of the normal UVRAG to mutated versions in melanoma cells and 50 fly eyes. After injecting the cells with UV radiation, they discovered that the normal gene repaired approximately twice as much damage as the mutated gene.USC researchers also collaborated with the Children’s Hospital Los Angeles, the Korea Advanced Institute of Science and Technology and the Chinese Academy of Sciences in Beijing. The study was funded by The Margaret Early Trustee Foundation, American Cancer Society, National Institutes of Health Grants and GRL Program from the National Research Foundation of Korea.This study provides a starting point for future drugs that could stimulate the repair mechanism of the gene for those who are at a high risk for melanoma. Liang says it can also be a helpful indicator for preventative measures.“In the age of precision medicine, doctors may suggest their patients who have risks of skin cancer (such as skin cancer family history, super sensitive to sunlight, etc.) to screen this sunscreen gene and suggest those who have reduced levels of UVRAG or mutant version to protect more against sun exposure, such as lathering on more sunscreen with higher SPF and cover up more in summer, reducing outdoor activities in straight sunlight for long time, etc.,” Liang said.
Fire danger is on Dave Roberts’ mind as Dodgers head to San Francisco How Dodgers pitcher Ross Stripling topped the baseball podcast empire Dodgers’ Max Muncy trying to work his way out of slow start Dodgers hit seven home runs, sweep Colorado Rockies Cody Bellinger homer gives Dodgers their first walkoff win of season PreviousLos Angeles Dodgers’ Max Muncy watches his RBI single during the fifth inning of the team’s baseball game against the Atlanta Braves on Wednesday, May 8, 2019, in Los Angeles. (AP Photo/Marcio Jose Sanchez)Justin Turner #10 of the Los Angeles Dodgers looks on against the Atlanta Braves in the fifth inning of a MLB baseball game at Dodger Stadium on Wednesday, May 8, 2019 in Los Angeles, California. (Photo by Keith Birmingham, Pasadena Star-News/SCNG) SoundThe gallery will resume insecondsAustin Barnes #15 of the Los Angeles Dodgers scores past Tyler Flowers #25 of the Atlanta Braves on a single by Max Muncy (not pictured) in the fifth inning of a MLB baseball game at Dodger Stadium on Wednesday, May 8, 2019 in Los Angeles, California. (Photo by Keith Birmingham, Pasadena Star-News/SCNG)Ozzie Albies #1 of the Atlanta Braves slides into third base safe on a RBI single by Josh Donaldson (not pictured) of the Atlanta Braves in the seventh inning of a MLB baseball game at Dodger Stadium on Wednesday, May 8, 2019 in Los Angeles, California. (Photo by Keith Birmingham, Pasadena Star-News/SCNG)Clayton Kershaw #22 of the Los Angeles Dodgers throws to the plated against the Atlanta Braves in the seventh inning of a MLB baseball game at Dodger Stadium on Wednesday, May 8, 2019 in Los Angeles, California. (Photo by Keith Birmingham, Pasadena Star-News/SCNG)Clayton Kershaw #22 of the Los Angeles Dodgers walks off the mound after being pulled from the game by manager Dave Roberts after giving up a run against the Atlanta Braves in the seventh inning of a MLB baseball game at Dodger Stadium on Wednesday, May 8, 2019 in Los Angeles, California. (Photo by Keith Birmingham, Pasadena Star-News/SCNG)Los Angeles Dodgers’ Justin Turner hits a two-run home run against the Atlanta Braves during the eighth inning of a baseball game Wednesday, May 8, 2019, in Los Angeles. (AP Photo/Marcio Jose Sanchez)Joe Kelly #17 of the Los Angeles Dodgers throws to the plate against the Atlanta Braves in the ninth inning of a MLB baseball game at Dodger Stadium on Wednesday, May 8, 2019 in Los Angeles, California. (Photo by Keith Birmingham, Pasadena Star-News/SCNG)Corey Seager #5 of the Los Angeles Dodgers bobbles a ground ball by Johan Camargo #17 of the Atlanta Braves in the eighth inning of a MLB baseball game at Dodger Stadium on Wednesday, May 8, 2019 in Los Angeles, California. (Photo by Keith Birmingham, Pasadena Star-News/SCNG)From left, Los Angeles Dodgers’ Chris Taylor, Alex Verdugo and Cody Bellinger celebrate after a win over the Atlanta Braves during a baseball game Wednesday, May 8, 2019, in Los Angeles. (AP Photo/Marcio Jose Sanchez)Los Angeles Dodgers’ Max Muncy watches his RBI single during the fifth inning of the team’s baseball game against the Atlanta Braves on Wednesday, May 8, 2019, in Los Angeles. (AP Photo/Marcio Jose Sanchez)NextShow Caption1 of 10Los Angeles Dodgers’ Max Muncy watches his RBI single during the fifth inning of the team’s baseball game against the Atlanta Braves on Wednesday, May 8, 2019, in Los Angeles. (AP Photo/Marcio Jose Sanchez)ExpandLOS ANGELES — Gene Simmons and Yoongi of BTS were here Tuesday night. The comedian known as “Fluffy” (Gabriel Iglesias) made an appearance Wednesday.Undistracted by such star power, the Dodgers kept on winning.They scored twice in the seventh inning and again in the eighth on Justin Turner’s fourth home run in the past two games to secure a 9-4 victory and complete a three-game sweep of the Atlanta Braves.Unlike last year’s six-week hole-digging to start the season, the Dodgers have not spent a day under .500 this season – and it doesn’t look like they will. They have won 10 of their last 13 games and three of their past four series (including two sweeps). Two of the three losses were by a single run and they have outscored their opponents 70-42 during this stretch. Newsroom GuidelinesNews TipsContact UsReport an Error But a grab bag of two walks (including the second intentional walk of Bellinger in the game) and three singles produced two runs in the bottom of the seventh. Corey Seager beat out an infield single for one run and Verdugo drove in the other with a single to center.Turner added his two-run home run in the eighth inning to put the game away.“It was one of those nights that can be super frustrating to think about personally so I’m going to choose not to and just focus on a great team win,” Kershaw said.“Giving up four runs is never fun. Giving up that home run after we scored is never fun. You want a shutdown inning there. A lot of things you can probably pick apart for my outing personally. But I’m going to try not to think about and just enjoy a win.”Dylan Floro and Joe Kelly closed it out, combining for 2-1/3 uneventful innings in relief – uneventful being an upgrade for Kelly. He needed just 11 pitches to retire the side in the ninth, striking out two in his first clean inning since April 16.“Like I said, before the game, for us to win a championship, we need Joe Kelly to get back to himself and tonight was a step in the right direction,” Roberts said. The Dodgers have the best record in the National League (25-14), the most wins in the majors and are only percentage points behind the Minnesota Twins (23-12) for the best record in baseball.“It definitely feels like when you come to the ballpark we’re going to win every night,” said Clayton Kershaw, Wednesday’s starting pitcher. “You know with the ebbs and flows of the season it’s not always going to feel that way. But right now it does. It feels like someone’s going to pick us up. If we’re down early, we’re going to come back. If we get the lead early, we’re going to hold it and add on.“There are just a lot of signs of a great team. Different guys contributing all the way through.”They took the direct route against the Braves, holding the lead after 26 of the 27 innings. Wednesday’s first inning was scoreless. But Kiké Hernandez’s two-run home run in the second inning put the Dodgers in front to stay. They responded with multi-run innings each time the Braves pulled within a run.Max Muncy drove in two runs – on a solo home run in the third and an RBI single in the fifth – and had three hits in the game. Over his past 11 games, Muncy has gone 15 for 39 (.385) with a double, three home runs and 14 RBIs. It is the kind of offensive production Muncy provided unexpectedly last season but is counted on to produce this year. “That’s always a challenge to follow up a great year, especially your first full year in the big leagues,” Dodgers manager Dave Roberts said. “Max is mentally tough. I think his DNA – and we’ve talked about this over the past year and a half – he’s just really good in the strike zone. Even when you’re out of whack mechanically, if you can still stay in the strike zone, you give yourself a chance.“The first month of the season he really wasn’t sound mechanically but he was able to sort of keep his head above water. So now when he gets hot, the numbers look right.”Turner tread water in April, batting .279 but slugging only .337 and not hitting a home run until the last day of the month. Like Muncy, he has warmed up with the turn of the calendar. Over his past 11 games, Turner is 18 for 46 (.391) with five home runs and 10 RBIs.“Just need to tell him the season starts May 1, I guess,” Kershaw said. “It’s not that he was swinging the bat that bad in April. It just wasn’t going over the fence. Now it’s going over the fence coupled with all his great at-bats that he’s continued to have all the way through.”Kershaw was less pleased with his own contributions Wednesday.He gave up a season-high nine hits while striking out a season-low four in his 6-2/3 innings and allowed more hard-hit balls that could have created trouble. Cody Bellinger ran down Josh Donaldson’s slicing drive in the right field corner to end the third inning. Alex Verdugo went to the warning track in center field twice to catch back-to-back long flies by Ronald Acuña Jr. and Nick Markakis in the sixth.The Braves did damage Kershaw’s bottom line in the fourth when Freddie Freeman’s double off the wall in right-center field was followed by a two-run home run by Acuña that made it a one-run game, 3-2.The Braves got to Kershaw again in the seventh with three consecutive two-out singles (two of which never left the infield), cutting the lead to two. When Freeman greeted Scott Alexander with an RBI single, it was a one-run game again, 5-4.Related Articles